{
  "layer": "modules",
  "paper": "gadeke-2026-guilt-insula",
  "modules": [
    {
      "id": "q1",
      "kind": "question",
      "question": "Does the larger decrease in momentary happiness after a low outcome for the partner when the participant made the choice reflect responsibility-contingent interpersonal guilt, rather than general agency aversion, disappointment over the participant's own outcome, a social shift in risk attitude, or inattentive task engagement?",
      "warrant": null,
      "summary": "Responsibility for a social choice that yields a low outcome for a partner produces interpersonal guilt, experienced by the decision-maker as a larger decrease in momentary happiness than when the partner made the same choice.",
      "hypotheses": [
        "responsibility-social-choice-yields-low"
      ],
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        {
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          "eliminated_by": [
            "participant-happiness-lower-when-participant"
          ]
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        {
          "slug": "alt-guilt-effect-driven-by-own-outcome",
          "eliminated_by": [
            "guilt-effect-occurred-whether-participant"
          ]
        },
        {
          "slug": "alt-participants-insensitive-to-value",
          "eliminated_by": [
            "participants-probability-choosing-risky-option"
          ]
        },
        {
          "slug": "alt-social-context-shifts-risk-attitude",
          "eliminated_by": [
            "participants-showed-very-similar-risk",
            "risk-premiums-not-differ-between"
          ]
        }
      ],
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              "finding": "when-partner-received-low-lottery",
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                "pre-task-icebreaker-succeeded-establishing-positive",
                "responsibility-choices-not-influence-happiness"
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                "responsibility-choices-not-influence-happiness"
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                "fig3d,fig3h"
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        },
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            {
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                "participant-momentary-happiness-varied-rewards-2",
                "participants-own-reward-prediction-errors",
                "responsibility-model-yielded-higher-values",
                "rutledge-colleagues-established-changes-momentary"
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                "fig3b,fig3f",
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            },
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                "participant-momentary-happiness-varied-rewards-2",
                "participants-own-reward-prediction-errors",
                "responsibility-model-yielded-higher-values",
                "rutledge-colleagues-established-changes-momentary"
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              },
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                "fig3b,fig3f",
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            },
            {
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              "warrant": null,
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              "panels": []
            },
            {
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            }
          ]
        }
      ],
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        {
          "finding": "guilt-effect-occurred-whether-participant",
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        },
        {
          "finding": "participant-happiness-lower-when-participant",
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          },
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        },
        {
          "finding": "participants-probability-choosing-risky-option",
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          },
          "panels": [
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          ]
        },
        {
          "finding": "participants-showed-very-similar-risk",
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            "no-significant-interaction-between-difference",
            "participants-chose-risky-option-lottery",
            "participants-slightly-more-risk-averse"
          ],
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            "supported_by": [
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              "participants-chose-risky-option-lottery",
              "participants-slightly-more-risk-averse"
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          },
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            "fig2a,fig2d",
            "fig2c,fig2f"
          ]
        },
        {
          "finding": "risk-premiums-not-differ-between",
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          },
          "panels": [
            "fig2b,fig2e"
          ]
        }
      ],
      "interpretations": [
        "behavioural-guilt-effect-larger-happiness",
        "both-studies-participants-felt-worse",
        "lower-happiness-when-participant-decision-maker"
      ],
      "domain": [
        "each-trial-participants-chose-between",
        "findings-rest-two-samples-healthy"
      ],
      "apparatus": [
        "linear-mixed-model-containing-all",
        "model-selection-among-happiness-models"
      ],
      "members": [
        "alt-agency-aversion-not-guilt",
        "alt-guilt-effect-driven-by-own-outcome",
        "alt-participants-insensitive-to-value",
        "alt-social-context-shifts-risk-attitude",
        "behavioural-guilt-effect-larger-happiness",
        "both-studies-participants-felt-worse",
        "guilt-effect-occurred-whether-participant",
        "likelihood-ratio-test-showed-responsibility",
        "linear-mixed-model-containing-all",
        "lower-happiness-when-participant-decision-maker",
        "mixed-effects-regressions-choices-social-condition",
        "no-significant-interaction-between-difference",
        "participant-happiness-lower-when-participant",
        "participant-momentary-happiness-varied-rewards",
        "participant-momentary-happiness-varied-rewards-2",
        "participants-chose-risky-option-lottery",
        "participants-own-reward-prediction-errors",
        "participants-probability-choosing-risky-option",
        "participants-showed-very-similar-risk",
        "participants-slightly-more-risk-averse",
        "partner-reward-prediction-errors-resulting",
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        "responsibility-choices-not-influence-happiness",
        "responsibility-model-yielded-higher-values",
        "responsibility-outcomes-generates-guilt-participant",
        "responsibility-partner-outcomes-influences-participant",
        "responsibility-social-choice-yields-low",
        "risk-premiums-not-differ-between",
        "rutledge-colleagues-established-changes-momentary",
        "when-partner-received-low-lottery"
      ]
    },
    {
      "id": "q2",
      "kind": "question",
      "question": "Is the anterior insula, together with its condition- and choice-dependent connectivity to prefrontal cortex, the neural substrate of this interpersonal guilt, responding more when the participant is responsible for a partner's low outcome?",
      "warrant": null,
      "summary": "The anterior insula is the neural substrate of the guilt effect, increasing its BOLD response when participants are responsible for low outcomes affecting their partner.",
      "hypotheses": [
        "anterior-insula-neural-substrate-guilt",
        "functional-connectivity-between-guilt-responsibility-related"
      ],
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        {
          "slug": "alt-imaging-contrast-invalid",
          "eliminated_by": [
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          ]
        }
      ],
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            {
              "finding": "insula-rois-responded-more-low",
              "warrant": null,
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                "difference-response-between-low-high",
                "dot-products-between-individual-neural",
                "during-outcome-phase-responses-low"
              ],
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                  "during-outcome-phase-responses-low"
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                "app1table9",
                "fig4e"
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                "dot-products-between-individual-neural",
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                  "during-outcome-phase-responses-low"
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              },
              "panels": [
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                "fig4e"
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            },
            {
              "finding": "mass-univariate-voxel-wise-analysis-found-small",
              "warrant": null,
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              "combine": {
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              },
              "panels": [
                "fig4f"
              ]
            },
            {
              "finding": "mass-univariate-voxel-wise-analysis-found-small",
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              "panels": [
                "fig4f"
              ]
            }
          ]
        },
        {
          "prediction": "connectivity-between-guilt-responsibility-related-outcome-ph",
          "outcome": "confirmed",
          "findings": [
            {
              "finding": "functional-connectivity-between-left-anterior",
              "warrant": null,
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                "fig5"
              ]
            },
            {
              "finding": "functional-connectivity-between-left-anterior",
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            }
          ]
        }
      ],
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        {
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          },
          "panels": [
            "fig4a"
          ]
        },
        {
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          },
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        },
        {
          "finding": "prior-literature-documents-association-between",
          "warrant": null,
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          "panels": []
        }
      ],
      "interpretations": [
        "connectivity-between-left-anterior-insula"
      ],
      "domain": [
        "study-reproduced-study-design-inside"
      ],
      "apparatus": [
        "during-receipt-lottery-versus-safe"
      ],
      "members": [
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        "anterior-insula-neural-substrate-guilt",
        "anterior-insula-tracks-guilt-insula",
        "bilateral-ventral-striatum-more-active",
        "connectivity-between-guilt-responsibility-related-outcome-ph",
        "connectivity-between-left-anterior-insula",
        "difference-response-between-low-high",
        "dot-products-between-individual-neural",
        "during-outcome-phase-responses-low",
        "functional-connectivity-between-guilt-responsibility-related",
        "functional-connectivity-between-left-anterior",
        "insula-rois-responded-more-low",
        "left-ifg-cluster-showed-opposite",
        "mass-univariate-voxel-wise-analysis-found-small",
        "prior-functional-connectivity-work-shown",
        "prior-literature-documents-association-between"
      ]
    },
    {
      "id": "q3",
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      "question": "Does a neural substrate track the participant's responsibility for the partner's outcomes, representing partner reward prediction errors more strongly when they arise from the participant's own choice than from the partner's choice?",
      "warrant": null,
      "summary": "A neural substrate tracks the participant's responsibility for the partner's outcomes: within regions sensitive to choice outcomes, the partner's reward prediction errors are represented more strongly when they arise from the participant's own choice than from the partner's choice.",
      "hypotheses": [
        "neural-substrate-tracks-participant-responsibility"
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          "slug": "alt-model-based-glm-invalid",
          "eliminated_by": [
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        }
      ],
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        {
          "prediction": "neural-substrate-tracks-participant-responsibility-2",
          "outcome": "confirmed",
          "findings": [
            {
              "finding": "one-cluster-left-sts-responded",
              "warrant": null,
              "results": [
                "left-superior-temporal-sulcus-cluster"
              ],
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                  "left-superior-temporal-sulcus-cluster"
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              },
              "panels": [
                "fig4h",
                "fig4i"
              ]
            },
            {
              "finding": "one-cluster-left-sts-responded",
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                "left-superior-temporal-sulcus-cluster"
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              },
              "panels": [
                "fig4h",
                "fig4i"
              ]
            }
          ]
        }
      ],
      "findings": [
        {
          "finding": "manipulation-check-bilateral-ventral-striatum",
          "warrant": null,
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          "panels": [
            "fig4g"
          ]
        }
      ],
      "interpretations": [
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        "model-based-glm-entered-best-fitting-computational"
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        "authors-suggest-left-sts-region",
        "left-superior-temporal-sulcus-cluster",
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        "neural-substrate-tracks-participant-responsibility",
        "neural-substrate-tracks-participant-responsibility-2",
        "one-cluster-left-sts-responded"
      ]
    },
    {
      "id": "o1",
      "kind": "observation",
      "question": null,
      "warrant": null,
      "summary": "Decisions in the Social compared with the Solo condition engaged three clusters — the precuneus (d = 0.79), left temporo-parietal junction (d = 0.59), and medial prefrontal cortex (d = 0.54).",
      "finding": {
        "finding": "decisions-social-compared-solo-condition",
        "warrant": null,
        "results": [
          "only-precuneus-tpj-showed-positive"
        ],
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        },
        "panels": [
          "fig4b",
          "fig4c"
        ]
      },
      "domain": [
        "each-trial-participants-chose-between"
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      "apparatus": [],
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      ]
    },
    {
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      "kind": "observation",
      "question": null,
      "warrant": null,
      "summary": "Individual GRBS dot-product values did not correlate with the behavioural guilt responses (Spearman's Rho = –0.058, p = 0.725), indicating the neural signature does not track individual differences in behavioural guilt sensitivity.",
      "finding": {
        "finding": "individual-grbs-dot-product-values-not",
        "warrant": null,
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        },
        "panels": []
      },
      "domain": [],
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      "members": [
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      ]
    },
    {
      "id": "o3",
      "kind": "observation",
      "question": null,
      "warrant": null,
      "summary": "The Responsibility Redux model — incorporating expected, previous and current rewards, reward prediction errors for both participant and partner, and decision-maker — predicted the variations in participants' momentary happiness well.",
      "finding": {
        "finding": "responsibility-redux-model-incorporating-expected",
        "warrant": null,
        "results": [
          "parameter-recovery-procedure-synthetic-data-generated"
        ],
        "combine": {
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            "parameter-recovery-procedure-synthetic-data-generated"
          ],
          "supported_by": [],
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        },
        "panels": [
          "fig3c,fig3g",
          "fig3s1"
        ]
      },
      "domain": [],
      "apparatus": [
        "momentary-happiness-modelled-five-computational"
      ],
      "members": [
        "parameter-recovery-procedure-synthetic-data-generated",
        "responsibility-redux-model-incorporating-expected"
      ]
    }
  ],
  "loose": [
    {
      "slug": "among-computational-models-fitted-momentary",
      "reason": "apparatus claim wanting a `requires` or `enables-method` edge from the finding that rests on it"
    },
    {
      "slug": "hold-partner-behaviour-constant-across",
      "reason": "apparatus claim wanting a `requires` or `enables-method` edge from the finding that rests on it"
    },
    {
      "slug": "risk-aversion-parameter-not-differ-between",
      "reason": "result reaching no placed finding; wants a `requires`, `supports`, `validates` or `tests` edge"
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  "owner": {
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    "alt-guilt-effect-driven-by-own-outcome": "q1",
    "alt-imaging-contrast-invalid": "q2",
    "alt-model-based-glm-invalid": "q3",
    "alt-participants-insensitive-to-value": "q1",
    "alt-social-context-shifts-risk-attitude": "q1",
    "anterior-insula-neural-substrate-guilt": "q2",
    "anterior-insula-tracks-guilt-insula": "q2",
    "authors-suggest-left-sts-region": "q3",
    "behavioural-guilt-effect-larger-happiness": "q1",
    "bilateral-ventral-striatum-more-active": "q2",
    "both-studies-participants-felt-worse": "q1",
    "connectivity-between-guilt-responsibility-related-outcome-ph": "q2",
    "connectivity-between-left-anterior-insula": "q2",
    "decisions-social-compared-solo-condition": "o1",
    "difference-response-between-low-high": "q2",
    "dot-products-between-individual-neural": "q2",
    "during-outcome-phase-responses-low": "q2",
    "functional-connectivity-between-guilt-responsibility-related": "q2",
    "functional-connectivity-between-left-anterior": "q2",
    "guilt-effect-occurred-whether-participant": "q1",
    "individual-grbs-dot-product-values-not": "o2",
    "insula-rois-responded-more-low": "q2",
    "left-ifg-cluster-showed-opposite": "q2",
    "left-superior-temporal-sulcus-cluster": "q3",
    "likelihood-ratio-test-showed-responsibility": "q1",
    "linear-mixed-model-containing-all": "q1",
    "lower-happiness-when-participant-decision-maker": "q1",
    "manipulation-check-bilateral-ventral-striatum": "q3",
    "mass-univariate-voxel-wise-analysis-found-small": "q2",
    "mixed-effects-regressions-choices-social-condition": "q1",
    "neural-substrate-tracks-participant-responsibility": "q3",
    "neural-substrate-tracks-participant-responsibility-2": "q3",
    "no-significant-interaction-between-difference": "q1",
    "one-cluster-left-sts-responded": "q3",
    "only-precuneus-tpj-showed-positive": "o1",
    "parameter-recovery-procedure-synthetic-data-generated": "o3",
    "participant-happiness-lower-when-participant": "q1",
    "participant-momentary-happiness-varied-rewards": "q1",
    "participant-momentary-happiness-varied-rewards-2": "q1",
    "participants-chose-risky-option-lottery": "q1",
    "participants-own-reward-prediction-errors": "q1",
    "participants-probability-choosing-risky-option": "q1",
    "participants-showed-very-similar-risk": "q1",
    "participants-slightly-more-risk-averse": "q1",
    "partner-reward-prediction-errors-resulting": "q1",
    "pre-task-icebreaker-succeeded-establishing-positive": "q1",
    "prior-functional-connectivity-work-shown": "q2",
    "prior-literature-documents-association-between": "q2",
    "responsibility-choices-not-influence-happiness": "q1",
    "responsibility-model-yielded-higher-values": "q1",
    "responsibility-outcomes-generates-guilt-participant": "q1",
    "responsibility-partner-outcomes-influences-participant": "q1",
    "responsibility-redux-model-incorporating-expected": "o3",
    "responsibility-social-choice-yields-low": "q1",
    "risk-premiums-not-differ-between": "q1",
    "rutledge-colleagues-established-changes-momentary": "q1",
    "when-partner-received-low-lottery": "q1"
  },
  "grain": {
    "alt-agency-aversion-not-guilt": "alternative",
    "alt-guilt-effect-driven-by-own-outcome": "alternative",
    "alt-imaging-contrast-invalid": "alternative",
    "alt-model-based-glm-invalid": "alternative",
    "alt-participants-insensitive-to-value": "alternative",
    "alt-social-context-shifts-risk-attitude": "alternative",
    "anterior-insula-neural-substrate-guilt": "hypothesis",
    "anterior-insula-tracks-guilt-insula": "prediction",
    "authors-suggest-left-sts-region": "interpretation",
    "behavioural-guilt-effect-larger-happiness": "interpretation",
    "bilateral-ventral-striatum-more-active": "finding",
    "both-studies-participants-felt-worse": "interpretation",
    "connectivity-between-guilt-responsibility-related-outcome-ph": "prediction",
    "connectivity-between-left-anterior-insula": "interpretation",
    "decisions-social-compared-solo-condition": "finding",
    "difference-response-between-low-high": "detail",
    "dot-products-between-individual-neural": "detail",
    "during-outcome-phase-responses-low": "detail",
    "functional-connectivity-between-guilt-responsibility-related": "hypothesis",
    "functional-connectivity-between-left-anterior": "finding",
    "guilt-effect-occurred-whether-participant": "finding",
    "individual-grbs-dot-product-values-not": "finding",
    "insula-rois-responded-more-low": "finding",
    "left-ifg-cluster-showed-opposite": "detail",
    "left-superior-temporal-sulcus-cluster": "detail",
    "likelihood-ratio-test-showed-responsibility": "finding",
    "linear-mixed-model-containing-all": "detail",
    "lower-happiness-when-participant-decision-maker": "interpretation",
    "manipulation-check-bilateral-ventral-striatum": "finding",
    "mass-univariate-voxel-wise-analysis-found-small": "finding",
    "mixed-effects-regressions-choices-social-condition": "detail",
    "neural-substrate-tracks-participant-responsibility": "hypothesis",
    "neural-substrate-tracks-participant-responsibility-2": "prediction",
    "no-significant-interaction-between-difference": "detail",
    "one-cluster-left-sts-responded": "finding",
    "only-precuneus-tpj-showed-positive": "detail",
    "parameter-recovery-procedure-synthetic-data-generated": "detail",
    "participant-happiness-lower-when-participant": "finding",
    "participant-momentary-happiness-varied-rewards": "detail",
    "participant-momentary-happiness-varied-rewards-2": "detail",
    "participants-chose-risky-option-lottery": "detail",
    "participants-own-reward-prediction-errors": "detail",
    "participants-probability-choosing-risky-option": "finding",
    "participants-showed-very-similar-risk": "finding",
    "participants-slightly-more-risk-averse": "detail",
    "partner-reward-prediction-errors-resulting": "finding",
    "pre-task-icebreaker-succeeded-establishing-positive": "detail",
    "prior-functional-connectivity-work-shown": "finding",
    "prior-literature-documents-association-between": "finding",
    "responsibility-choices-not-influence-happiness": "detail",
    "responsibility-model-yielded-higher-values": "detail",
    "responsibility-outcomes-generates-guilt-participant": "prediction",
    "responsibility-partner-outcomes-influences-participant": "prediction",
    "responsibility-redux-model-incorporating-expected": "finding",
    "responsibility-social-choice-yields-low": "hypothesis",
    "risk-premiums-not-differ-between": "finding",
    "rutledge-colleagues-established-changes-momentary": "detail",
    "when-partner-received-low-lottery": "finding"
  }
}