Abstract ↔ claims
run not observed · v1 provisional awaiting approvalWhich claims does the abstract carry, and which does it drop?
for Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy · this layer across all papers · json
Provisional
This layer needs a corpus-scope decision that has not been ruled on yet, so what it produces would change if the decision changed. It waits on claim-format, relation-vocab.
Awaiting approval
Waiting for approval. That is a statement about the record, not about whether anyone has read this: people read the corpus without stamping what they read, and only a stamp leaves a trace. Approval is an operation on a version, not a step of its own — it is recorded against the version it was granted to, so running this layer again does not carry it forward.
What this layer produced
Abstract mapped to claims
The paper's abstract is shown with each sentence linked to the claim(s) it represents in the dependency graph. Hover or click a sentence to highlight the corresponding claim cards. Below: what the graph contains that the abstract leaves out, and vice versa.
1The recurrent pathogenic variant KCNC1-p.Ala421Val (A421V) is a cause of developmental and epileptic encephalopathy characterized by moderate-to-severe developmental delay/intellectual disability, and infantile-onset treatment-resistant epilepsy with multiple seizure types, including myoclonic seizures. 2Yet, the mechanistic basis of this disease, and of the KCNC1 disease spectrum, remains unclear. 3KCNC1 encodes Kv3.1, a voltage-gated potassium channel subunit that is strongly and selectively expressed in neurons capable of generating action potentials at high frequency, including parvalbumin-positive fast-spiking GABAergic inhibitory interneurons in cerebral cortex (PV-INs) that are known to be important for cognitive function and plasticity as well as control of network excitation to prevent seizures. 4In this study, we generate a novel transgenic mouse model with conditional expression of the A421V pathogenic missense variant (Kcnc1-A421V/+ mice) to explore the specific physiological mechanisms of KCNC1 developmental and epileptic encephalopathy. 5Our results indicate that global heterozygous expression of the A421V variant leads to cognitive impairment, epilepsy, and premature lethality. 6We observe decreased PV-IN cell surface expression of Kv3.1 via immunohistochemistry, decreased voltage-gated potassium current density in PV-INs using outside-out nucleated macropatch recordings in brain slice, and profound impairments in the intrinsic excitability of cerebral cortex PV-INs (but not excitatory neurons) via current-clamp electrophysiology. 7In vivo two-photon calcium imaging revealed altered activity in Kcnc1-A421V/+ PV-INs and excitatory cells, as well as hypersynchronous discharges correlated with brief paroxysmal movements that were subsequently shown to be myoclonic seizures on electroencephalography. 8We found alterations in PV-IN-mediated inhibitory neurotransmission in young adult but not juvenile Kcnc1-A421V/+ mice relative to wild-type controls. 9Together, these results establish the specific impact of the recurrent Kv3.1-A421V variant on neuronal excitability and synaptic physiology across development to drive network dysfunction underlying KCNC1 epileptic encephalopathy.
- D1 a421v-weight-reduced-milestones-normal fig1—figure supplement 2B, 2C, 2D, 2E Kcnc1-A421V/+ mice show significantly reduced body and brain weight relative to WT littermates, but display no detectable abnormalities in gross developmental milestones (fur appearance, eye opening, ear canal opening, incisor eruption, motor benchmarks) assessed at P5–15.
- H3.P2.1 layer-v-pv-ins-subtle-impairment fig4—figure supplement 2 Layer V neocortical PV-INs from juvenile (P16–21) Kcnc1-A421V/+ mice show more subtle abnormalities than layer II-IV PV-INs: AP frequency reduction is confined to the largest current injection magnitudes (***p<0.001 for genotype × current injection interaction), consistent with the higher relative expression of Kv3.2 vs Kv3.1 in deeper cortical layers.
- H3.P2.2 rtn-neurons-impaired-excitability fig4—figure supplement 3 Parvalbumin-positive reticular thalamic nucleus (RTN) neurons from juvenile (P16–21) Kcnc1-A421V/+ mice generate fewer rebound APs in response to hyperpolarizing current and show attenuated frequency-current relationship (*p=0.0109), with significantly reduced AP downstroke velocity (*p=0.034) but preservation of other membrane properties.
- H3.P2 prediction-impairment-grades-with-kv31-dependence prediction Phenotype magnitude across PV-IN populations should grade with Kv3.1 dependence: superficial cortical (largest), layer V (mildest), RTN (intermediate, distinctive rebound-firing pattern).
How it is defined
A model answers this layer, so the prompt is the layer. It is reproduced below from the committed file, and it is a declared input — editing it makes every run that used it stale.
The declaration names this path and the repository does not have it. An input that does not exist hashes to nothing, so it cannot make a run stale — the layer is declared to depend on something it is not in fact tracking.
Artifacts
Versions
From the run ledger. There is no changelog beside it to keep in step.
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v1 · 2026-04-20 · unrecorded backfilled from the artifact
backfilled from the artifact on disk
This layer across the corpus
Across the corpus
9 run not observed · 1 stale·a paper links to its own cell, where this layer's output for it is rendered
Inputs and outputs
- Reads, besides its dependencies
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- extract/prompts/abstract-map.md · declared, and not in the repository — it hashes to nothing, so it cannot make a run stale
- Produces
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- site/src/data/abstract-mapping/{paper}.json
One per paper — the table above links each one that exists.
- Views
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- document — rendered above, from the artifact itself
- comparison — on the cell page, two versions aligned by the matcher, wherever the ledger holds more than one
Running it
The command comes from the declaration, so this text and what actually runs cannot
diverge. pipeline.py run also runs the unmet dependencies first.
python3 scripts/pipeline.py run <paper> abstract-map
Underneath, that runs cd extract && python3 -m claim_graphs.cli abstract-map --paper {paper}.